Protein family key to aging, cancer

Tuesday, October 18, 2011

The list of aging-associated proteins known to be involved in cancer is growing longer, according to research by investigators at Vanderbilt-Ingram Cancer Center and the National Institutes of Health (NIH).

The new study, published Oct. 17 in Cancer Cell, identifies the protein SIRT2 as a tumor suppressor linked to gender-specific tumor development in mice. Along with two other "sirtuin" proteins previously linked to cancer, the new finding suggests the existence of a rare "family" of tumor suppressors.

Cancer is primarily a disease of aging, with the majority of cancer cases occurring in people over 50. However, the biological processes that underlie this association are not clear.

In the late-1990s, sirtuins were linked to extended lifespan observed in several species maintained on a calorically restricted diet. These nutrient-sensing proteins seemed to defend against aging-related cellular damage.

"The single most important prognostic factor in cancer is increasing age," said Gius, a professor of Radiation Oncology and associate professor of Cancer Biology at Vanderbilt-Ingram. "It seems logical that the genes that play a role in aging ? or perhaps better stated, anti-aging ? would be connected to cancer."

While at the NIH's National Cancer Institute, Gius and colleagues found that when they eliminated SIRT3 ? a sirtuin localized in the mitochondria, the cellular "power plants" ? the mice developed ER/PR positive breast tumors, the most common type of breast cancer in postmenopausal women.

In the new study, Gius' lab ? working with senior author Chu-Xia Deng, Ph.D., and colleagues at the NIH's National Institute of Diabetes and Digestive and Kidney Diseases ? investigated the physiological functions of SIRT2 by eliminating the protein in cultured cells and in mice.

They found that SIRT2-deficient mice developed tumors in multiple tissues ? and, strangely, male mice and female mice developed tumors in different tissues. Lack of SIRT2 in female mice led to mammary (breast) tumors, while male mice lacking SIRT2 developed a range of gastrointestinal tumors (in the liver, pancreas, colon and stomach).

"It's kind of a startling observation, that you'd knock a protein out, and you'd get gender-specific tumors, suggesting a physiological connection between gender and the function of sirtuin proteins" Gius said.

From human cancer data, the investigators showed that SIRT2 was also decreased in human cases of breast cancer, gastrointestinal tumors (which were not broken down by gender), and several other cancer types.

While the mechanism underlying the gender-specific tumors was not determined, the researchers did find evidence that SIRT2 acted as a tumor suppressor in cultured cells. Specifically, the protein appeared to regulate an important part of the machinery involved in cell division ? a protein complex called APC/C. Loss of SIRT2 led to "genomic instability," or an abnormal segregation of chromosomes during cell division. While the cells at first showed reduced proliferation, their growth rate gradually increased and the cells showed signs of malignant transformation.

Previous studies indicated that two other members of the sirtuin family ? SIRT1 and SIRT3 ? have tumor suppressor functions. These findings suggest that a third member of this protein family acts as a tumor suppressor.

"You don't normally find families of tumor suppressor genes," Gius said. "They're kind of lone wolves?it's just not common to find a family of (tumor suppressor) genes, especially ones connected to aging."

Because the mammary tumors that develop in female mice appear similar to the most common type of breast cancer (luminal breast cancers), Gius believes these mice could provide a much-needed animal model for that disease.

His group plans to investigate whether SIRT2 is a "driver" of luminal breast cancer and, if so, to use the mice as a model for investigating chemopreventive agents.

"Ultimately, we could possibly identify subgroups of women who might benefit from the agents we validate in mice," he said.

###

Vanderbilt University Medical Center: http://www.mc.vanderbilt.edu/npa

Thanks to Vanderbilt University Medical Center for this article.

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Source: http://www.labspaces.net/114364/Protein_family_key_to_aging__cancer

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UK band Stone Roses reunite 15 years on for world tour (Reuters)

LONDON (Reuters) ? Manchester rockers The Stone Roses, who rose to fame in the late 1980s before fading almost as fast less than a decade later, have reunited for a world tour kicking off in their home town next June.

The quartet's eponymous debut album, released in 1989, is considered one of the greatest records to come out of British rock.

They produced just one more studio album, "Second Coming," in 1994, although lead singer Ian Brown hinted that there could be a third in the works.

"We hope so, but we said that before didn't we?" he told a London press conference on Tuesday.

Asked why the band had reformed 15 years after splitting, Brown replied: "Because I think we're great and I think we've still got it and I think we've still got something to give to people, and I think that in times like this we can uplift people."

The tour starts on June 29, 2012, with the first of two gigs at Manchester's Heaton Park. Further details of the tour have yet to be released.

The reformed group will feature what most people consider to be the core quartet -- vocalist Brown, guitarist John Squire, bass player Gary "Mani" Mounfield and drummer Alan "Reni" Wren.

All four were at the briefing, ending months of speculation that they would reform.

Earlier this year, however, Squire poured cold water on the idea and was quoted by NME music magazine as saying: "When it's just a get-together for a big payday and everyone gets their old clothes out, that seems tragic to me."

Seeking to explain his change of heart, he told reporters: "Everything changed when me and Ian started seeing each other again. It was surreal. We went from crying and laughing about the old days to writing songs in a heartbeat.

"I think it's in some ways a friendship that defines us both and it needed fixing and two phone calls later the band was no longer dead."

The catalyst for their reunion was Mani's mother's funeral, he said.

Mani, who will have to give up playing with Primal Scream for the foreseeable future, added: "Beautiful things come out of a really sad situation."

Brown denied the reunion was about money, saying the group had had many invitations in the past to get back together.

Asked to comment on fellow Mancunian musician Shaun Ryder's comment recently that he was doing it to fund his divorce, Brown joked: "There's always truth in Shaun Ryder's comments."

The Stone Roses join a long list of British bands who have reformed in recent years, from ex-boy band Take That to indie rockers Pulp and from Blur to Spandau Ballet.

Some fans are skeptical about their motives, putting musicians' urge to bury hatchets down to cynical commercialism at a time when top acts can still earn a small fortune from a single live tour.

But tickets tend to sell out fast, underlining ongoing demand for disbanded acts to reform.

The Stone Roses formed in Manchester in 1983, and were among the pioneers of a musical movement known as "Madchester" in the late 1980s and 1990s that also included New Order and the Happy Mondays.

The second, and final, studio album hit stores in 1994, but never matched the acclaim of their debut.

Reni left the group in 1995, when The Stone Roses played a sellout tour of Britain. Guitarist and songwriter Squire quit in 1996, prompting the band's swift demise.

(Reporting by Mike Collett-White, editing by Paul Casciato)

Source: http://us.rd.yahoo.com/dailynews/rss/music/*http%3A//news.yahoo.com/s/nm/20111018/music_nm/us_stoneroses_reunion

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Jackson doctor's defense will get chance

The trial of Michael Jackson's personal physician will enter a new phase this week, with the doctor's attorneys trying to counter three weeks of damaging testimony and attempting to show that the singer somehow caused his own death.

Lawyers for Dr. Conrad Murray have told jurors that the involuntary manslaughter case will hinge on the science of what killed Jackson in June 2009. They will call their own experts to counter prosecution witnesses who have repeatedly told the panel that Murray was reckless and beyond the fringes of medicine when he administered the anesthetic propofol to help Jackson sleep.

It was not clear when the defense would get to start its presentation. Monday's testimony was canceled because the government's final witness, Dr. Steven Shafer, will be unavailable. Court spokeswoman Mary Hearn said Sunday the trial's resumption would be announced when more information becomes available.

The Houston-based cardiologist has pleaded not guilty and his attorneys continue to maintain that Jackson somehow gave himself the fatal dose of medication. They have abandoned the theory that Jackson died after swallowing propofol, but now contend he was killed after taking several pills of the sedative lorazepam and possibly giving himself a shot of propofol after Murray left the singer's bedroom.

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Before the defense lays out its case ? expected to consist of 15 witnesses and last until the end of the month ? it will have to contend with Shafer. The Columbia University researcher and professor helped write the warnings and directions included with every vial of propofol ? warnings a prosecutor said in opening statements that Murray ignored.

Defense attorney Nareg Gourjian declined to say Friday who Murray's team would call to testify, but told the judge they would include police officers, experts and some character witnesses. He was not asked, nor did he mention, whether Murray would testify in his own defense.

Story: Jackson trial focuses on singer's Demerol use

It seems unlikely that Murray will testify. Jurors have already heard his more-than-two-hour interview in which he laid out his version of events before Jackson's death to a detective who acknowledges he wasn't conducting an interrogation.

If Murray takes the stand, he would undoubtedly be asked by prosecutors about several unanswered questions, such as why he never told paramedics or ER doctors about giving Jackson propofol, why he never told police he was on the phone for long stretches of the morning Jackson died, and why he recorded the singer when he was impaired, stumbling his way through his plans for a children's hospital and cementing a legacy larger than those attained by Elvis Presley or The Beatles.

In his opening statement to jurors, lead defense attorney Ed Chernoff said Murray's team would try to answer two fundamental questions:

"First, how did Michael Jackson get to this point, this desperate point," Chernoff said. "And second, what happened when Dr. Murray was out of the room?"

Prosecution witnesses have acknowledged that only Jackson and Murray know what really happened, but two medical experts testified last week that Murray was grossly negligent. Even if Jackson somehow was able to give himself medication after Murray left the room, the doctor should have been closely monitoring the singer and should have never left any medications within arms' reach, the doctors said.

Ellyn Garofalo, who last year won an acquittal for one of Anna Nicole Smith's doctors charged with improperly prescribing pain medications, said Murray's team should focus on their expert testimony and not start calling character witnesses.

Slideshow: Michael Jackson?s life and career (on this page)

"If they start to call character witnesses, they don't have a great deal of faith in their defense," she said.

She said the experts should be able to show that the case isn't as simple as prosecutors have claimed, and that it is filled with "all kinds of shades of gray."

Murray's attorneys should also try to argue that prosecutors should not be second-guessing medical decisions. "Do we really want the DA's office making medical decisions for doctors," she asked.

Murray's case, she noted, differs in one major respect from the case against her client, who was never accused of causing Smith's death.

Garofalo said Murray's case will be harder to win, and prosecutors so far have done a solid job of showing that the doctor shouldn't have been giving Jackson propofol as a sleep aid in the superstar's bedroom.

Slideshow: Jackson's face changed over the years (on this page)

"It's a strong case because you have somebody dead after somebody did something that is unheard of," Garofalo said.

Murray's defense strategy also appears to involve calling hostile witnesses, including police officers who prosecutors did not call during their case. The defense scored some points early in the trial by getting a coroner's investigator to acknowledge that she moved some evidence around in Jackson's bedroom before photographing it and that she didn't keep all her notes. The officers would likely undergo the similar harsh questioning about their decisions.

They may also call doctors who previously treated Jackson but have never been formally accused of wrongdoing. They are barred from calling one doctor whose name has been repeatedly mentioned during the trial ? Jackson's longtime dermatologist Dr. Arnold Klein.

Murray's team may also call Jackson's hairdresser, Karen Faye, who they have said will testify that the singer was distraught at the prospect of performing 50 comeback concerts at London's O2 arena. Such an account would be in contrast with several other witnesses who said Jackson was excited about the concerts and that his three children would see him perform.

The trial, which is entering its fourth week, has moved rapidly, with 33 witnesses so far and both sides presenting more than 250 pieces of evidence. At its current pace, jurors should receive the case next week.

Is there anything Murray's lawyers could present that would make you believe he is innocent? Tell us on Facebook.

Source: http://today.msnbc.msn.com/id/44922034/ns/today-entertainment/

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99% The Interrupters

The Interrupters bares more than a passing resembles to the HBO TV series The Wire - except it's a documentary and it's all true. At nearly three hours, this searing, immersive documentary looks at a group called CeaseFire, an organization in Chicago set up by a doctor who has theorised that the cycle of violence spreads like a virus, and that preventative measures might be better than, for example, increasing police. Some areas in Chicago have exceptionally high rates of violent crime and statistically a young person is more likely to die from a shooting or stabbing than from anything else. "The Interrupters" refers to the brave group of people, all of whom who have grown up in Chicago and whom in their past have experienced first hand the drugs, violence, and incarceration that practically seems predetermined in some areas, and who now talk to individuals and groups and act as peacekeepers, or, where necessary, 'interrupters' literally putting themselves in the midst of dangerous scenes to stop violence escalating, and to prevent retaliatory violence and shootings. The documentary concentrates on three of these interrupters and offers throughout the film details about the pasts and what they now do in CeaseFire. Often times their role might just be to listen to what people are saying, or to calm them down, and sometimes they might have to be much more involved. We get to follow some of the people they are working with or the groups they are involved with, and they run the gamut from working one-to-one to get estranged brothers talking to themselves and their mother, through to work with classes of schoolchildren on anti-violence projects, through to speaking at funerals to beg for the violence to stop, or to ensure the people their are with make a promise to not retaliate - all of which has varying but absolutely noticeable effect in terms of violence committed. One especially powerful moment shows one of the interrupters literally breaking up a fight in the moment rocks are thrown - surely preventing murder on the streets in broad daylight. Though clocking in at nearly three hours, there's barely a frame that seems misplaced and if anything the film could have been even more exhaustive (we barely see for example, the involvements of police or government aside from a few news clips and archive footage) though this would surely have been at the expensive of the personal stories, all of which are touching. The Interrupters themselves should be seen as nothing less than heroes; their work is valuable and certainly saves lives.

August 13, 2011

Source: http://www.rottentomatoes.com/m/the_interrupters_2011/

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Republicans Polish Old Rhetoric and Call it a 'New Jobs Plan' (ContributorNetwork)

COMMENTARY | "We were tired of Obama campaigning around saying we don't have we don't have a jobs plan when we've had one for nine months, so we codified it into a bill," said Sen. Rand Paul, R-Ky., (and son of crazed Rep. Ron Paul, R-Texas) Thursday.

Paul was referring to the "Jobs Through Growth Act," a Republican Senate bill co-sponsored by Sen. John McCain, R-Ariz. According to the Daily Caller, among provisions in the "nine-month"- old plan were a balanced budget, a line-item veto, reduced corporate income tax. Sen. McCain quipped: "[Democrats] believe that government and spending creates jobs. We believe business and growth creates jobs."

Give me a break. Sometimes it's tough to know where to begin dissecting the mis-truths floated by politicians. For example, the balanced budget amendment was first proposed by Harold Knutson, R-Min., in 1936, and has failed in the Congress every time it has been proposed or voted upon. As they supposedly say more often in red states than in blue, "That dog won't hunt." It's not a new idea. Next?

When it comes to the line item veto, presidents since Grant (in 1876) have been requesting that mechanism. It passed in 1996, but was quickly shot down by judicial review. Again, this is not a 9-month-old idea. It's older than anyone alive and has been a perpetual point of contention for more than a century.

As to lowering corporate taxes, perhaps Paul and McCain didn't get the memo, but the general public isn't overly thrilled with the idea of continuing to push crony capitalism. It's not just a bad idea, but as Yosemite Sam says: "Them's fightin' words."

I won't presume to speak for all Americans, but for my part I am sick of seeing politicians on both sides of the aisle drag out tired old legislation that they know won't fly. It's become a game of cheap parlor tricks with no substance wherein both parties drag out their old, beaten down war horses, call them options, and then cry "foul" when the opposing side does what is expected and balks.

Dear Congress, we the people don't have time for you to continue to play politics with our lives. And in case you missed the latest polling data, neither do you.

Source: http://us.rd.yahoo.com/dailynews/rss/gop/*http%3A//news.yahoo.com/s/ac/20111014/us_ac/10202173_republicans_polish_old_rhetoric_and_call_it_a_new_jobs_plan

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Leyland enjoying quite a ride with Tigers (AP)

DETROIT ? In his 20 seasons as a major league manager, Jim Leyland has won two pennants and a World Series ? so far.

This year's Detroit Tigers have work to do if they want to add to Leyland's haul. They trail the Texas Rangers 3-2 in the AL championship series. But no matter what happens this weekend when the teams meet again, Leyland seems determined to enjoy every moment.

The veteran manager says he's not sure he's ever been prouder of a team than this one.

At the start of the year, Leyland faced an uncertain future, with his contract set to expire after the 2011 season. He received a one-year extension in August, just before the Tigers pulled away to win the AL Central easily.

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/ap/20111014/ap_on_sp_ba_ne/bba_alcs_leyland_s_ride

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Canadian Finance Carnival #58 ? Canadian Finance Blog

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Budgeting

Echo at Boomer & Echo presents 11 Steps To Financial Freedom: Compare Your Spending To Your Goals, saying ?I hope to develop a complete financial plan through these 11 steps to financial freedom. Step 4 is to compare your spending to your goals.?

Business

Philip at PT Money Personal Finance presents How to Organize a Successful Peer Conference: Behind the Scenes at the Financial Blogger Conference, saying ?Instead of doing another recap, I thought I would provide some information about how the conference was conceived and planned ? a behind the scenes look, if you will.?

Kelly at Create Hype presents When the Customers You Have Aren?t the Ones You Want, saying ?What to do when the customers you have aren?t the customers you want and how to embrace your best customers.?

Career

Neal Frankle at Wealth Pilgirm presents Which Job Is Right For Me?, saying ??Which job is right for me?? This is a question I hear both from college grads and from people looking for jobs without a college degree. Jobs are hard to find. If you are considering a new job or career, you might be so happy to get an offer that you?ll take the first one that comes along.?

Darwin at Darwin?s Money presents Would You Ever Write a Negative Recommendation?, saying ?Would You Ever Write a ?Negative? Recommendation? It could kill a career, which is what almost happened to me.?

Gerry Sandis at Resume Mag presents 28 Questions To Ask Yourself Before Accepting A Job Offer, saying ?You may have spent the last few weeks, or even months, looking for a job and it can be very tempting to immediately accept the first thing that comes your way. Remember, this is going to be your new career, so you don?t want to be too hasty with your decision. Take your time to evaluate the offer and consider the following questions:?

Debt and Credit

Jon the Saver at Free Money Wisdom presents Biblical View on Paying with Cash to Get Out of Debt, saying ?So simple, yet so powerful. Pay cash from now on, pay your debts faithfully and even if you do nothing else, in a few years, you?ll be debt free.?

Mike at Rewards Cards Canada presents TD Travel Rewards Review, saying ?TD Travel Rewards offers three different options for personal travel rewards credit cards. Choosing the right card depends on your spending habits and income level.?

Economy

Big Cajun Man at THE Canadian Personal Finance Site presents Optimistic Labour Numbers, saying ? Following two months of little change, employment rose by 61,000 in September, all in full time. This increase pushed the unemployment rate down 0.2 percentage points to 7.1%, the lowest rate since December 2008. Pretty good news, don?t you think? Given the media pundits had been saying we would be lucky to be ?holding steady? at the current rate, 61,000 new jobs is pretty darn good, way to go Canadian Economy!?

Extra Income

Jason at Live Real, Now presents Make Extra Money, Part 6: Setting Up a Site, saying ?In this installment of the Make Extra Money series, I?m going to show you how to set up a WordPress site. I?m going to show you exactly what settings, plugins, and themes I use.?

Beating Broke at Beating Broke presents Quick and Easy Passive Income Ideas, saying ?There are several ways you can set up some small passive income streams that will provide with different forms of passive income. Here?s a few passive income ideas.?

Frugality

Corey at 20?s Finances presents Can You Be Too Frugal, saying ?Obsessing over living a frugal lifestyle can be overwhelming. What level of frugality is too much and what is healthy??

Mike Collins at Stupid Cents presents Family Fun on a Budget, saying ?Here are some ideas for having some family fun on a budget, helping you save money since so many family activities cost you and arm and a leg.?

Investing

Mich at BeatingTheIndex presents Aroway Energy: A Rising Junior Oil Company in Alberta?s Hot Peace River Arch Area, saying ?What makes this rising junior oil producer in the Peace River Arch Area of North Western Alberta so special? ?

Lifestyle

Kevin at Invest It Wisely presents Steve Jobs: Entrepreneur and Capitalist Extraordinaire, saying ?On Wednesday, the world lost a great entrepreneur and capitalist, a man whose creativity and genius sparked an entire industry and changed the face of computing and communication forever. That man was Steve Jobs.?

Craig Ford at Money Help For Christians presents Why Every Missionary Needs A Kindle or Nook, saying ?Learn the value of having a Nook or Kindle if you live overseas.?

N.W. Journey at Net Worth Journey presents Please Talk about Money?It?s Important, saying ?Money discussions are important in all areas of life.?

D.J. at The Family Wallet presents Tips on How to Choose an Online Password and Keep It Safe, saying ?You know how important online security is; why not try some of these tips on how to choose an online password and keep it safe??

Kelsey at Money Mum presents How to Save Money at the Airport, saying ?Spending some money at the airport is probably inevitable, but there are steps to take to avoid incurring extreme charges ? and save money during your trip. ?

Kelly at Wallet Watcher presents Four Ways a Healthy Lifestyle Brings Better Finances, saying ?When it comes to the issue of money, few people would link it to your own personal health. However, studies have proven that there is not just one, but several links between healthy lifestyles and financial stability. A few simple changes to your spending or health habits can work wonders for you, as the two go hand in hand?

Emmie at Frugal Living presents 6 Personal Finance Tips from Our Elders, saying ?Current retires enjoy a high rate of home-ownership because they have learnt to squirrel their money away for emergency and future needs. ?

Outlaw at Outlaw Finance presents Eco-Friendly Updates Every Home Owner Should Know, saying ?Earth-friendly updates are a great place to start to reduce your carbon footprint and get on the path to creating and maintaining a greener home.?

Glen Craig at Free From Broke presents The New American Family: Flexibility and Unconventional Lifestyles to Make Ends Meet , saying ?Today?s economy has changed the face of domestic living and who stays to watch the kids. More American families are living unconventional lifestyles to make ends meet.?

Briana at Personal Dividends presents 20 Money Lessons for 20 Somethings, saying ?A lot of money lessons are expensive to learn, often coming after they made mistakes that cost them money. Here are 20 money lessons for 20 somethings, in case they didn?t know them before.?

Real Estate

Sustainable PF at Sustainable Personal Finance presents Eco Friendly Houses with Real Curb Appeal, saying ?There are an increasing number of ?Green Houses? that deliver stunning design and eco-friendly elements in a perfect package.?

Retirement

Jim Yih at Retire Happy Blog presents How to avoid probate fees?, saying ?Doing estate planning solely to avoid the probate process and probate fees is like choosing the place you retire based solely on the weather.?

Group Benefits Guy at Group Benefits Online presents How many funds should you have in your Group Retirement Savings Plan?, saying ?One key decision that must be made when setting up a Group Retirement Savings Plan is the number of investment options available to the members.?

Saving

SavingMentor at HowToSaveMoney.ca presents 11 Car Buying Tips To Get the Best New Car Price, saying ?Over the years I?ve learned many car buying tips and tricks from various friends and relatives as well as from my own online and offline research. I have been buying vehicles for about 18 years and these tips can and do work very well.?

Other

Caroline Hanna at Fun n? Finance presents How can money help you live your best life?, saying ?Asking yourself some key questions so you can use money to achieve the things that REALLY matter to you and enrich you life. ?

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Source: http://canadianfinanceblog.com/canadian-finance-carnival-58/

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Indonesia sentences jihadist to 8 years (AP)

JAKARTA, Indonesia ? An Indonesian militant was sentenced Thursday to eight years in prison for helping set up a terrorist cell plotting attacks on Western hotels and embassies in the capital.

Abu Tholut is among more than 120 alleged members of "Tanzim Al Qaeda in Aceh" captured or killed since authorities discovered their jihadi training camp in westernmost Aceh province early last year.

Judge Musa Arif Aini told the West Jakarta District Court the 50-year-old Islamic militant helped set up the camp and procure M16 assault rifles and other weapons for the group.

Tholut, also known as Mustofa, became one of Indonesia's most-wanted fugitives after Noordin Top and Dulmatin ? master bomb makers for the al-Qaida-linked Jemaah Islamiyah network ? were killed in police raids last year.

He was convicted for involvement in a 2001 bomb blast at a shopping plaza in central Jakarta that wounded six. He served five years of an eight-year sentence and was released for good behavior.

Like dozens of other convicted Islamist extremists in the world's most populous Muslim nation he returned to his terrorist network after his release.

Indonesia was thrust onto the front lines of the battle against terrorism in 2002, when Jemaah Islamiyah militants bombed two crowded nightclubs on the resort island of Bali, killing 202 people, many of them foreign tourists.

There have been several suicide bombings targeting Western hotels, restaurants and an embassy since then, but all have been far less deadly. The last occurred more than two years ago.

Source: http://us.rd.yahoo.com/dailynews/rss/terrorism/*http%3A//news.yahoo.com/s/ap/20111013/ap_on_re_as/as_indonesia_terrorism_trial

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